Fasting Hyperglycemia and Insulin Resistance in Colorectal Adenomatous Polyps

OBJECTIVES: To investigate fasting glucose, glucose tolerance, insulin resistance and insulin–like growth factor 1 in patients with or without colorectal polyps. MATERIALS AND METHODS: In this cross-sectional study, we evaluated fasting glucose, insulin, insulin–like growth factor 1 (IGF-1), lipid profile and glucose tolerance test in 103 patients undergoing colonoscopy (52 normal and 53 with Adenomatous polyps). We also estimated homeostasis model assessment insulin resistance index (HOMA-IR) in two groups. Statistical analyses were performed using the Student T-test and Chi-square test. For all tests a P value ≤ 0.05 was considered to be statistically significant. RESULTS: The mean of waist circumference (P < 0.01), waist to hip ratio (P < 0.01), fasting serum glucose (P < 0.05), total cholesterol (P < 0.05), and LDL (P < 0.05) were significantly higher in patients with adenomatous polyps. The mean of HDL was significantly lower in patients with adenomatous polyps (P < 0.01). There was no relation between fasting serum insulin, IGF-1 and glucose tolerance test with adenomatous polyps. Hence HOMA-IR was higher in patients with adenomatous polyps (2.9 ± 2.6 vs. 2.82 ± 2.1), this difference was not significant statistically. CONCLUSION: Fasting hyperglycemia could be a risk factor to adenomatous polyps’ development. Although this study did not show any relation between insulin resistance index and adenomatous polyps, further studies are needed for more evaluation.